The discovery of histone demethylase LSD1 is an important progress in the field of epigenetics, indicating that histone lysine methylation is a reversible and dynamic process like other covalent histone modifications such as acetylation, phosphorylation and ubiquitylation.Structural and functional research results demonstrate that LSD1 regulates the activation and silencing of gene transcription and the function of p53. LSD1 plays a significant role in the development of several cancers and is a potential target protein for developing anti-cancer drugs.

Adenosine triphosphate（ATP） binding cassette transporters, known as ABC transporters, is a kind of active transporters which can be found in all kingdoms of life. It normally consists of four domains: two transmembrane domains (TMD) and two nucleotide-binding domains (NBD). NBDs hydrolyzes ATPs, and the produced energy can be used by TMDs to transport substrates across the membrane against the chemical potential. ABC transporters anticipate in a variety of physiological process, because almost all functional molecules can be recognized as substrates by ABC transporters. The human genome encodes 48 ABC transporters in total, and dysfunction of the transporters is directly related to some major diseases. This essay summarized the classification and features of human ABCs, and emphasized the latest research progress of structure studies of human ABC transporters, as well as their relations with human diseases.

The current research achievements show that the dynamic time warping (DTW) is the best measure in most area of time series similarity measurements. However, the high time complexity for calculating DTW distance directly, and the fact that DTW does not satisfy the triangle inequality, render it impossible to deduce TWD quickly. Nowadays DTW optimizing methods are mainly devoted to designing low time complexity DTW low bound distances with low time complexity to accelerate time series comparison. Unfortunately, these DTW low bound distances cannot be deduced, either. Therefore, it must be compared one by one to compute time series similarity, which has high I/O cost. A novel educible DTW low bound distance is thus proposed, along with a corresponding index building method and a similar time series query algorithm. It is the first research on the DTW deducing problem. Extended experiment results show that compared to current technologies, the proposed method is efficient in both time complexity and I/O cost.