ISSN 0253-2778

CN 34-1054/N

Open AccessOpen Access JUSTC

UCBT is the best transplant type for separation of GVHD and GVL

Cite this:
https://doi.org/10.3969/j.issn.0253-2778.2018.10.004
  • Received Date: 18 July 2018
  • Rev Recd Date: 06 September 2018
  • Publish Date: 31 October 2018
  • Umbilical cord blood (CB) has now become one of the most commonly used sources of hematopoietic stem cells (HSCs) for allogeneic transplantation. Substantial advances have been made resulting in better outcomes for patients. Many studies have shown a decreased relapse rate and a reduced chronic graft-versus-host disease (cGVHD) rate with an increased GVHD-free/relapse-free survival (GRFS) rate and better quality of life after allogeneic hematopoietic stem cells transplantation (HCT) with CB compared with other donor sources. With the technical improvement of cord blood transplantation (CBT), unrelated umbilical cord blood transplantation (UCBT) is being gradually used to treat a wider range of patients, such as those with non-hematological malignancies and aged patients. This paper reviewed the current status of diagnosis and treatment of UCBT.
    Umbilical cord blood (CB) has now become one of the most commonly used sources of hematopoietic stem cells (HSCs) for allogeneic transplantation. Substantial advances have been made resulting in better outcomes for patients. Many studies have shown a decreased relapse rate and a reduced chronic graft-versus-host disease (cGVHD) rate with an increased GVHD-free/relapse-free survival (GRFS) rate and better quality of life after allogeneic hematopoietic stem cells transplantation (HCT) with CB compared with other donor sources. With the technical improvement of cord blood transplantation (CBT), unrelated umbilical cord blood transplantation (UCBT) is being gradually used to treat a wider range of patients, such as those with non-hematological malignancies and aged patients. This paper reviewed the current status of diagnosis and treatment of UCBT.
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