ISSN 0253-2778

CN 34-1054/N

Open AccessOpen Access JUSTC

Synergistic toxicity of bulk zinc oxide and cadmium chloride in mice

Cite this:
https://doi.org/10.3969/j.issn.0253-2778.2014.08.003
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  • Author Bio:

    GAO Shang, male, born in 1990, master. Research field: bioinorganic chemistry. E-mail: gaos@mail.ustc.edu.cn

  • Corresponding author: XU Xiaolong
  • Received Date: 30 May 2014
  • Rev Recd Date: 17 June 2014
  • Publish Date: 31 August 2014
  • The wide applications of zinc oxide (ZnO) and ubiquitous cadmium (Cd) pollution have increased the risk of humans co-exposure to ZnO and Cd. The synergistic toxicity of bulk ZnO and CdCl2 in mice was investigated. Mice were randomly divided into four groups: a control group and three experimental groups (bulk ZnO, CdCl2, bulk ZnO+CdCl2). Bulk ZnO shows low toxicity in mice. In contrast, CdCl2 causes siginificant damage in the liver indicated by severe liver dysfunction and histopathological abnormalities. Although co-exposure to bulk ZnO and CdCl2 has positive synergistic effects on the uptakes of Zn and Cd in the liver, bulk ZnO can significantly alleviate CdCl2-induced damage in the liver. The bulk ZnO-induced metallothionein synthesis and the inhibition of Cd-induced deprivation of tissue Zn by bulk ZnO might play two key roles in the protective effect of bulk ZnO on CdCl2-induced damage in the liver.
    The wide applications of zinc oxide (ZnO) and ubiquitous cadmium (Cd) pollution have increased the risk of humans co-exposure to ZnO and Cd. The synergistic toxicity of bulk ZnO and CdCl2 in mice was investigated. Mice were randomly divided into four groups: a control group and three experimental groups (bulk ZnO, CdCl2, bulk ZnO+CdCl2). Bulk ZnO shows low toxicity in mice. In contrast, CdCl2 causes siginificant damage in the liver indicated by severe liver dysfunction and histopathological abnormalities. Although co-exposure to bulk ZnO and CdCl2 has positive synergistic effects on the uptakes of Zn and Cd in the liver, bulk ZnO can significantly alleviate CdCl2-induced damage in the liver. The bulk ZnO-induced metallothionein synthesis and the inhibition of Cd-induced deprivation of tissue Zn by bulk ZnO might play two key roles in the protective effect of bulk ZnO on CdCl2-induced damage in the liver.
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