Abstract
Exosomes are extracellular vesicles that can be secreted by a variety of cells in the body. The lipid bilayer composed of membrane proteins is surrounded by proteins and nucleic acids, and has a diameter ranging from 30 to 100 nm. It contains genetic materials such as microRNAs(miRNAs) and mRNAs, and has functions such as material exchange and information transmission between cells, and it has a non-negligible effect on many physiological and pathological processes in the body. In recent years, miRNAs in exosomes have attracted the attention of scholars at home and abroad. They have been found to be involved in tumorigenesis, development, tumor angiogenesis, etc. To better understand the role of miRNAs in exosomes in gliomas, this paper reviewed the relationship between miRNAs in exosomes and the development and progression of glioma, tumor angiogenesis, and tumor metabolism, and explored their research progress in the diagnosis and treatment of glioma.
Abstract
Exosomes are extracellular vesicles that can be secreted by a variety of cells in the body. The lipid bilayer composed of membrane proteins is surrounded by proteins and nucleic acids, and has a diameter ranging from 30 to 100 nm. It contains genetic materials such as microRNAs(miRNAs) and mRNAs, and has functions such as material exchange and information transmission between cells, and it has a non-negligible effect on many physiological and pathological processes in the body. In recent years, miRNAs in exosomes have attracted the attention of scholars at home and abroad. They have been found to be involved in tumorigenesis, development, tumor angiogenesis, etc. To better understand the role of miRNAs in exosomes in gliomas, this paper reviewed the relationship between miRNAs in exosomes and the development and progression of glioma, tumor angiogenesis, and tumor metabolism, and explored their research progress in the diagnosis and treatment of glioma.
Open Access
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