Abstract
NLRP3 is an important intracellular pattern recognition receptor, which can form inflammasome with ASC and pro-caspase-1. Formation of NLRP3 inflammasome leads to maturity and secretion of inflammatory cytokines, such as IL-1β and IL-18, and then causes the inflammation. Dysregulation of NLRP3 inflammasome is associated with several human diseases, such as gout, atherosclerosis, neurodegenerative diseases and type 2 diabetes, so NLRP3 inflammasome is a potential target for treatment of those diseases, and several NLRP3 inflammasome inhibitors have shown preventive or therapeutic effects on NLRP3-driven diseases. In this paper the recent research advance of NLRP3 inflammasome inhibitor was briefly reviewed.
Abstract
NLRP3 is an important intracellular pattern recognition receptor, which can form inflammasome with ASC and pro-caspase-1. Formation of NLRP3 inflammasome leads to maturity and secretion of inflammatory cytokines, such as IL-1β and IL-18, and then causes the inflammation. Dysregulation of NLRP3 inflammasome is associated with several human diseases, such as gout, atherosclerosis, neurodegenerative diseases and type 2 diabetes, so NLRP3 inflammasome is a potential target for treatment of those diseases, and several NLRP3 inflammasome inhibitors have shown preventive or therapeutic effects on NLRP3-driven diseases. In this paper the recent research advance of NLRP3 inflammasome inhibitor was briefly reviewed.
Open Access
JUSTC
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