Anticancer effect of Kean Cream in vivo and in vitro on mouse melanoma skin cancer via transdermal drug delivery

School of Life Sciences, University of Science and Technology of China, Hefei 230027, China

Anqing Anticancer & Analgesia Research Institute, Anqing 246001, China) Abstract: To investigate the anticancer effect of Kean Cream, in which realgar nanoparticles are the main ingredient, a transdermal drug delivery system was applied to tumor tissues to increase its bioavailability and decrease its toxicity. The results show that Kean Cream could significantly suppress the proliferation and induce apoptosis of B16 melanoma cells, both in a dose-dependent manner, and tests in vivo show that Kean Cream can decrease tumor volume markedly compared to the control. Furthermore, HE stain revealed that Kean Cream can inhibit angiogenesis. Meanwhile, Kean at this concentration has little side-effect on mice. These results suggest that Kean Cream is a potential efficient transdermal anticancer agent. Key words: Kean Cream