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Highly perfluorocarbon loading efficiency of polymer biomimetic nanoparticle encapsulated by erythrocyte membrane to improve tumor phototherapy

  • Department of Gastroenterology, The First Affiliated Hospital of USTC(Anhui Provincial Hospital), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China

Cite this:
https://doi.org/10.52396/JUST-2021-0101
  • Received Date: 07 April 2021
  • Rev Recd Date: 29 April 2021
  • Publish Date: 31 August 2021
    Abstract

  • Abstract

    Photodynamic therapy (PDT) is an emerging treatment method that relies on oxygen. However, due to the insufficient oxygen supply to the blood vessels at the tumor site, the hypoxic microenvironment greatly inhibits the therapeutic effect of PDT. Therefore, how to alleviate the tumor hypoxia is the key issue of the development of PDT. Perfluorocarbon is a compound that can effectively carry oxygen and is one of the commonly used blood substitutes. We carry oxygen and photothermal drug Indocyanine Green (ICG) through PFC (bromide hepta-fluorooctane) nanoparticles, and coat the particles with red blood cell membranes for bionic camouflage to reduce the uptake of particles by macrophages, improve the circulation capacity of the particles and enhance the ability of the drug to accumulate in the tumor. In addition, we combine PDT to effectively alleviate the hypoxia in the tumor microenvironment, enhance the photodynamic effect, and provide new strategies for cancer therapies.

    Abstract

    Photodynamic therapy (PDT) is an emerging treatment method that relies on oxygen. However, due to the insufficient oxygen supply to the blood vessels at the tumor site, the hypoxic microenvironment greatly inhibits the therapeutic effect of PDT. Therefore, how to alleviate the tumor hypoxia is the key issue of the development of PDT. Perfluorocarbon is a compound that can effectively carry oxygen and is one of the commonly used blood substitutes. We carry oxygen and photothermal drug Indocyanine Green (ICG) through PFC (bromide hepta-fluorooctane) nanoparticles, and coat the particles with red blood cell membranes for bionic camouflage to reduce the uptake of particles by macrophages, improve the circulation capacity of the particles and enhance the ability of the drug to accumulate in the tumor. In addition, we combine PDT to effectively alleviate the hypoxia in the tumor microenvironment, enhance the photodynamic effect, and provide new strategies for cancer therapies.
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    • References(21)
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    Tohme S, Yazdani H O, Al-Khafaji A B, et al.Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress.Cancer Research,2016, 76 (6): 1367-1380.
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    Day A T, Sher D J, Lee R C, et al.Head and neck oncology during the COVID-19 pandemic: Reconsidering traditional treatment paradigms in light of new surgical and other multilevel risks.Oral Oncology,2020, 105: 8.
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    Szakacs G, Paterson J K, Ludwig J A, et al.Targeting multidrug resistance in cancer.Nature Reviews Drug Discovery,2006, 5 (3): 219-234.
    [4]
    Riley R S, June C H, Langer R, et al.Delivery technologies for cancer immunotherapy.Nature Reviews Drug Discovery,2019, 18 (3): 175-196.
    [5]
    Hopper C.Photodynamic therapy: a clinical reality in the treatment of cancer.The Lancet Oncology,2000, 1: 212-219.
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    Chen J M, Fan T J, Xie Z J, et al.Advances in nanomaterials for photodynamic therapy applications: Status and challenges.Biomaterials,2020, 237: 27.
    [7]
    Allison R R, Moghissi K.Photodynamic therapy (PDT): PDT mechanisms[J].Clinical Endoscopy,2013, 46 (1): 24-29.
    [8]
    Yang B W, Chen Y, Shi J L.Reactive oxygen species (ROS)-based nanomedicine.Chemical Reviews,2019, 119 (8): 4881-4985.
    [9]
    Carmeliet P, Jain R K.Angiogenesis in cancer and other diseases.Nature,2000, 407 (6801): 249-257.
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    Lee C, Lim K, Kim S S, et al.Chlorella-gold nanorods hydrogels generating photosynthesis-derived oxygen and mild heat for the treatment of hypoxic breast cancer.Journal of Controlled Release,2019, 294: 77-90.
    [11]
    Stylianopoulos T, Jain R K.Combining two strategies to improve perfusion and drug delivery in solid tumors.Proceedings of the National Academy of Sciences of the United States of America,2013, 110 (46): 18632-18637.
    [12]
    Phua S Z F, Yang G B, Lim W Q, et al.Catalase-integrated hyaluronic acid as nanocarriers for enhanced photodynamic therapy in solid tumor.Acs Nano,2019, 13 (4): 4742-4751.
    [13]
    Riess J G.Perfluorocarbon-based oxygen delivery.Artificial Cells Blood Substitutes and Biotechnology,2006, 34 (6): 567-580.
    [14]
    Blanco E, Shen H, Ferrari M.Principles of nanoparticle design for overcoming biological barriers to drug delivery.Nature Biotechnology,2015, 33 (9): 941-951.
    [15]
    Arafa M G, Mousa H A, Afifi N N.Preparation of PLGA-chitosan based nanocarriers for enhancing antibacterial effect of ciprofloxacin in root canal infection.Drug Delivery,2020, 27 (1): 26-39.
    [16]
    Zare E N, Jamaledin R, Naserzadeh P, et al.Metal-based nanostructures/PLGA nanocomposites: Antimicrobial activity, cytotoxicity, and their biomedical applications.Acs Applied Materials & Interfaces,2020, 12 (3): 3279-3300.
    [17]
    Wang L, Jiang W, Xiao L, et al.Self-reporting and splitting nanopomegranates potentiate deep tissue cancer radiotherapy via elevated diffusion and transcytosis.Acs Nano,2020, 14 (7): 8459-8472.
    [18]
    Jiang W, Zhang Z, Wang Q, et al.Tumor reoxygenation and blood perfusion enhanced photodynamic therapy using ultrathin graphdiyne oxide nanosheets.Nano Letters,2019, 19 (6): 4060-4067.
    [19]
    Gao M, Liang C, Song X J, et al.Erythrocyte-membrane-enveloped perfluorocarbon as nanoscale artificial red blood cells to relieve tumor hypoxia and enhance cancer radiotherapy.Advanced Materials,2017, 29 (35): 7.
    [20]
    Bahmani B, Bacon D, Anvari B.Erythrocyte-derived photo-theranostic agents:Hybrid nano-vesicles containing indocyanine green for near infrared imaging and therapeutic applications.Scientific Reports,2013, 3: 2180.
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    Zheng X H, Xing D, Zhou F F, et al.Indocyanine green-containing nanostructure as near infrared dual-functional targeting probes for optical imaging and photothermal therapy.Molecular Pharmaceutics,2011, 8 (2): 447-456.
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    [1]
    Tohme S, Yazdani H O, Al-Khafaji A B, et al.Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress.Cancer Research,2016, 76 (6): 1367-1380.
    [2]
    Day A T, Sher D J, Lee R C, et al.Head and neck oncology during the COVID-19 pandemic: Reconsidering traditional treatment paradigms in light of new surgical and other multilevel risks.Oral Oncology,2020, 105: 8.
    [3]
    Szakacs G, Paterson J K, Ludwig J A, et al.Targeting multidrug resistance in cancer.Nature Reviews Drug Discovery,2006, 5 (3): 219-234.
    [4]
    Riley R S, June C H, Langer R, et al.Delivery technologies for cancer immunotherapy.Nature Reviews Drug Discovery,2019, 18 (3): 175-196.
    [5]
    Hopper C.Photodynamic therapy: a clinical reality in the treatment of cancer.The Lancet Oncology,2000, 1: 212-219.
    [6]
    Chen J M, Fan T J, Xie Z J, et al.Advances in nanomaterials for photodynamic therapy applications: Status and challenges.Biomaterials,2020, 237: 27.
    [7]
    Allison R R, Moghissi K.Photodynamic therapy (PDT): PDT mechanisms[J].Clinical Endoscopy,2013, 46 (1): 24-29.
    [8]
    Yang B W, Chen Y, Shi J L.Reactive oxygen species (ROS)-based nanomedicine.Chemical Reviews,2019, 119 (8): 4881-4985.
    [9]
    Carmeliet P, Jain R K.Angiogenesis in cancer and other diseases.Nature,2000, 407 (6801): 249-257.
    [10]
    Lee C, Lim K, Kim S S, et al.Chlorella-gold nanorods hydrogels generating photosynthesis-derived oxygen and mild heat for the treatment of hypoxic breast cancer.Journal of Controlled Release,2019, 294: 77-90.
    [11]
    Stylianopoulos T, Jain R K.Combining two strategies to improve perfusion and drug delivery in solid tumors.Proceedings of the National Academy of Sciences of the United States of America,2013, 110 (46): 18632-18637.
    [12]
    Phua S Z F, Yang G B, Lim W Q, et al.Catalase-integrated hyaluronic acid as nanocarriers for enhanced photodynamic therapy in solid tumor.Acs Nano,2019, 13 (4): 4742-4751.
    [13]
    Riess J G.Perfluorocarbon-based oxygen delivery.Artificial Cells Blood Substitutes and Biotechnology,2006, 34 (6): 567-580.
    [14]
    Blanco E, Shen H, Ferrari M.Principles of nanoparticle design for overcoming biological barriers to drug delivery.Nature Biotechnology,2015, 33 (9): 941-951.
    [15]
    Arafa M G, Mousa H A, Afifi N N.Preparation of PLGA-chitosan based nanocarriers for enhancing antibacterial effect of ciprofloxacin in root canal infection.Drug Delivery,2020, 27 (1): 26-39.
    [16]
    Zare E N, Jamaledin R, Naserzadeh P, et al.Metal-based nanostructures/PLGA nanocomposites: Antimicrobial activity, cytotoxicity, and their biomedical applications.Acs Applied Materials & Interfaces,2020, 12 (3): 3279-3300.
    [17]
    Wang L, Jiang W, Xiao L, et al.Self-reporting and splitting nanopomegranates potentiate deep tissue cancer radiotherapy via elevated diffusion and transcytosis.Acs Nano,2020, 14 (7): 8459-8472.
    [18]
    Jiang W, Zhang Z, Wang Q, et al.Tumor reoxygenation and blood perfusion enhanced photodynamic therapy using ultrathin graphdiyne oxide nanosheets.Nano Letters,2019, 19 (6): 4060-4067.
    [19]
    Gao M, Liang C, Song X J, et al.Erythrocyte-membrane-enveloped perfluorocarbon as nanoscale artificial red blood cells to relieve tumor hypoxia and enhance cancer radiotherapy.Advanced Materials,2017, 29 (35): 7.
    [20]
    Bahmani B, Bacon D, Anvari B.Erythrocyte-derived photo-theranostic agents:Hybrid nano-vesicles containing indocyanine green for near infrared imaging and therapeutic applications.Scientific Reports,2013, 3: 2180.
    [21]
    Zheng X H, Xing D, Zhou F F, et al.Indocyanine green-containing nanostructure as near infrared dual-functional targeting probes for optical imaging and photothermal therapy.Molecular Pharmaceutics,2011, 8 (2): 447-456.
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