ISSN 0253-2778

CN 34-1054/N

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Open AccessOpen Access JUSTC Original Paper

Protective effect of Fe3O4 nanoparticles on cadmium chloride-induced toxicity in the small intestine of mice

Funds:  Supported by the National Natural Science Foundation of China (22076177, 21171157, 51973204).
Cite this:
https://doi.org/10.3969/j.issn.0253-2778.2020.07.003
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  • Author Bio:

    WANG Xiaoqin, female, born in 1992, master. Research field: bioinorganic chemistry. E-mail: qwang666@mail.ustc.edu.cn

  • Corresponding author: XU Xiaolong
  • Received Date: 16 April 2020
  • Accepted Date: 08 June 2020
  • Rev Recd Date: 08 June 2020
  • Publish Date: 31 July 2020
    Abstract

  • Abstract

    Synergistic toxicity from multiple environmental pollutants poses greater threat to humans. Here we evaluated combined toxicity of environment pollutants Fe3O4 nanoparticles (nano-Fe3O4) and cadmium chloride (CdCl2) in the small intestine of mice. The results showed that Fe3O4 nanoparticles (nano-Fe3O4) and CdCl2 have a negative synergistic toxicity in the small intestine of mice. Oral nano-Fe3O4 did not show obvious toxicity in the small intestine of mice. In contrast, oral CdCl2 caused significant oxidative stress in the small intestine of mice. CdCl2-induced oxidative stress resulted in inflammatory response in the small intestine as indicated by the significant increases in the levels of cyclooxygenase-2 and nitric oxide synthase as well as the inflammatory cell infiltration in the small intestinal tissue. Co-exposure to nano-Fe3O4 and CdCl2 significantly attenuated the CdCl2-induced damage in the small intestine through reduction of oxidative stress and inflammatory response.

    Abstract

    Synergistic toxicity from multiple environmental pollutants poses greater threat to humans. Here we evaluated combined toxicity of environment pollutants Fe3O4 nanoparticles (nano-Fe3O4) and cadmium chloride (CdCl2) in the small intestine of mice. The results showed that Fe3O4 nanoparticles (nano-Fe3O4) and CdCl2 have a negative synergistic toxicity in the small intestine of mice. Oral nano-Fe3O4 did not show obvious toxicity in the small intestine of mice. In contrast, oral CdCl2 caused significant oxidative stress in the small intestine of mice. CdCl2-induced oxidative stress resulted in inflammatory response in the small intestine as indicated by the significant increases in the levels of cyclooxygenase-2 and nitric oxide synthase as well as the inflammatory cell infiltration in the small intestinal tissue. Co-exposure to nano-Fe3O4 and CdCl2 significantly attenuated the CdCl2-induced damage in the small intestine through reduction of oxidative stress and inflammatory response.
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    • References(36)
  • [1]
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    LV X, JIANG G, XUE X, et al. Fe0-Fe3O4 nanocomposites embedded polyvinyl alcohol/sodium alginate beads for chromium (VI) removal [J]. J Hazard Mater, 2013, 262: 748-758.
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    GEBRAEL C, JUMARIE C. Cadmium interference with ERK1/2 and AhR signaling without evidence for cross-talk [J]. Toxicol Res, 2015, 4(6): 1488-1497.
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    KLAASSEN C D, LIU J, DIWAN B A. Metallothionein protection of cadmium toxicity [J]. Toxicol Appl Pharm, 2009, 238(3): 215-220.
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    ZHANG Y, XU X, ZHU S, et al. Combined toxicity of Fe3O4 nanoparticles and cadmium chloride in mice [J]. Toxicol Res, 2016, 5(5): 1309-1317.
    [22]
    ARRUEBO M, FERN NDEZ-PACHECO R, IBARRA M R, et al. Magnetic nanoparticles for drug delivery [J]. Nano Today, 2007, 2(3): 22-32.
    [23]
    CHEN H M, LANGER R. Magnetically-responsive polymerized liposomes as potential oral delivery vehicles [J]. Pharmaceutical research, 1997, 14(4): 537-540.
    [24]
    HAHN P F, STARK D D, LEWIS J M, et al. First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging [J]. Radiology, 1990, 175(3): 695-700.
    [25]
    GUO M, XU X, YAN X, et al. In vivo biodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice [J]. J Hazard Mater, 2013, 260: 780-788.
    [26]
    WANG X, GONG J, GUI Z, et al. Halloysite nanotubes-induced Al accumulation and oxidative damage in liver of mice after 30-day repeated oral administration [J]. Environmental Toxicology, 2018, 33(6): 623-630.
    [27]
    RAJA K B, JAFRI S E, PETERS T J, et al. Iron and cadmium uptake by duodenum of hypotransferrinaemic mice [J]. Biometals, 2006, 19(5): 547-553.
    [28]
    KWONG R W, NIYOGI S. Cadmium transport in isolated enterocytes of freshwater rainbow trout: interactions with zinc and iron, effects of complexation with cysteine, and an ATPase-coupled efflux [J]. Comp Biochem Physiol C Toxicol Pharmacol, 2012, 155(2): 238-246.
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    DJUKIC-COSIC D, CURCIC JOVANOVIC M, PLAMENAC BULAT Z, et al. Relation between lipid peroxidation and iron concentration in mouse liver after acute and subacute cadmium intoxication [J]. J Trace Elem Med Biol, 2008, 22(1): 66-72.
    [30]
    CHMIELNICKA J, CHERIAN M G. Environmental exposure to cadmium and factors affecting trace-element metabolism and metal toxicity [J]. Biol Trace Elem Res, 1986, 10(3): 243-262.
    [31]
    GROTEN J P, SINKELDAM E J, MUYS T, et al. Interaction of dietary Ca, P, Mg, Mn, Cu, Fe, Zn and Se with the accumulation and oral toxicity of cadmium in rats [J]. Food Chem Toxicol, 1991, 29(4): 249-258.
    [32]
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    JIHEN EL H, FATIMA H, NOUHA A, et al. Cadmium retention increase: a probable key mechanism of the protective effect of zinc on cadmium-induced toxicity in the kidney [J]. Toxicol Lett, 2010, 196(2): 104-109.
    [34]
    KUWANO T, NAKAO S, YAMAMOTO H, et al. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis [J]. Faseb J, 2004, 18(2): 300-310.
    [35]
    PORTER D W, MILLECCHIA L L, WILLARD P, et al. Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation [J]. Toxicol Sci, 2006, 90(1): 188-197.
    [36]
    MOULIS J M. Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals [J]. Biometals, 2010, 23(5): 877-896.)
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    [1]
    KILIC G, COSTA C, FERNANDEZ-BERTOLEZ N, et al. In vitro toxicity evaluation of silica-coated iron oxide nanoparticles in human SHSY5Y neuronal cells [J]. Toxicol Res, 2016, 5(1): 235-247.
    [2]
    ZHU X J, ZHOU J, CHEN M, et al. Core-shell Fe3O4@NaLuF4:Yb,Er/Tm nanostructure for MRI, CT and upconversion luminescence tri-modality imaging [J]. Biomaterials, 2012, 33(18): 4618-4627.
    [3]
    WANG J, CHEN Y, CHEN B, et al. Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice [J]. Int J Nanomedicine, 2010, 5: 861-866.
    [4]
    LV X, JIANG G, XUE X, et al. Fe0-Fe3O4 nanocomposites embedded polyvinyl alcohol/sodium alginate beads for chromium (VI) removal [J]. J Hazard Mater, 2013, 262: 748-758.
    [5]
    YUAN Q, LI N, CHI Y, et al. Effect of large pore size of multifunctional mesoporous microsphere on removal of heavy metal ions [J]. J Hazard Mater, 2013, 254-255: 157-165.
    [6]
    WANG Z, WU D, WU G, et al. Modifying Fe3O4 microspheres with rhodamine hydrazide for selective detection and removal of Hg2+ ion in water [J]. J Hazard Mater, 2013, 244-245: 621-627.
    [7]
    ZHANG L, WANG W, SHANG M, et al. Bi2WO6@carbon/Fe3O4 microspheres: preparation, growth mechanism and application in water treatment [J]. J Hazard Mater, 2009, 172(2/3): 1193-1197.
    [8]
    LEARENG S K, UBOMBA-JASWA E, MUSEE N. Toxicity of zinc oxide and iron oxide engineered nanoparticles to Bacillus subtilis in river water systems [J]. Environ Sci-Nano, 2020, 7(1): 172-185.
    [9]
    NEL A, XIA T, MADLER L, et al. Toxic potential of materials at the nanolevel [J]. Science, 2006, 311(5761): 622-627.
    [10]
    IVERSEN N K, FRISCHE S, THOMSEN K, et al. Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice [J]. Toxicol Appl Pharmacol, 2013, 266(2): 276-288.
    [11]
    ZHANG B, YANG B, ZHAI C, et al. The role of exendin-4-conjugated superparamagnetic iron oxide nanoparticles in beta-cell-targeted MRI [J]. Biomaterials, 2013, 34(23): 5843-5852.
    [12]
    PARK E J, KIM H, KIM Y, et al. Inflammatory responses may be induced by a single intratracheal instillation of iron nanoparticles in mice [J]. Toxicology, 2010, 275: 65-71.
    [13]
    MUTHUSAMY S, PENG C, NG J C. The binary, ternary and quaternary mixture toxicity of benzo[a] pyrene, arsenic, cadmium and lead in HepG2 cells [J]. Toxicol Res, 2016, 5(2): 703-713.
    [14]
    GEBRAEL C, JUMARIE C. Cadmium interference with ERK1/2 and AhR signaling without evidence for cross-talk [J]. Toxicol Res, 2015, 4(6): 1488-1497.
    [15]
    KLAASSEN C D, LIU J, DIWAN B A. Metallothionein protection of cadmium toxicity [J]. Toxicol Appl Pharm, 2009, 238(3): 215-220.
    [16]
    GONG J C,ZHANG Y,GUI Z X,HU T T,WANG X Q,WANG Z Y,XU X L.Combined toxicity of Fe3O4 nanoparticles and cadmium chloride in the liver of mice by oral route [J]. Journal of University of Science and Technology of China,2019,49(6):431-438.
    [17]
    AL HAMOUZ O C S, ESTATIE M, SALEH T A. Removal of cadmium ions from wastewater by dithiocarbamate functionalized pyrrole based terpolymers [J]. Sep Purif Technol, 2017, 177: 101-109.
    [18]
    CHAND P, BAFANA A, PAKADE Y B. Xanthate modified apple pomace as an adsorbent for removal of Cd (II), Ni (II) and Pb (II), and its application to real industrial wastewater [J]. Int Biodeter Biodegr, 2015, 97: 60-66.
    [19]
    CHAI L Y, LI H, YANG Z H, et al. Heavy metals and metalloids in the surface sediments of the Xiangjiang River, Hunan, China: distribution, contamination, and ecological risk assessment [J]. Environ Sci Pollut R, 2017, 24(1): 874-885.
    [20]
    SATARUG S, GARRETT S H, SENS M A, et al. Cadmium, environmental exposure, and health outcomes [J]. Environ Health Perspect, 2010, 118(2): 182-190.
    [21]
    ZHANG Y, XU X, ZHU S, et al. Combined toxicity of Fe3O4 nanoparticles and cadmium chloride in mice [J]. Toxicol Res, 2016, 5(5): 1309-1317.
    [22]
    ARRUEBO M, FERN NDEZ-PACHECO R, IBARRA M R, et al. Magnetic nanoparticles for drug delivery [J]. Nano Today, 2007, 2(3): 22-32.
    [23]
    CHEN H M, LANGER R. Magnetically-responsive polymerized liposomes as potential oral delivery vehicles [J]. Pharmaceutical research, 1997, 14(4): 537-540.
    [24]
    HAHN P F, STARK D D, LEWIS J M, et al. First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging [J]. Radiology, 1990, 175(3): 695-700.
    [25]
    GUO M, XU X, YAN X, et al. In vivo biodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice [J]. J Hazard Mater, 2013, 260: 780-788.
    [26]
    WANG X, GONG J, GUI Z, et al. Halloysite nanotubes-induced Al accumulation and oxidative damage in liver of mice after 30-day repeated oral administration [J]. Environmental Toxicology, 2018, 33(6): 623-630.
    [27]
    RAJA K B, JAFRI S E, PETERS T J, et al. Iron and cadmium uptake by duodenum of hypotransferrinaemic mice [J]. Biometals, 2006, 19(5): 547-553.
    [28]
    KWONG R W, NIYOGI S. Cadmium transport in isolated enterocytes of freshwater rainbow trout: interactions with zinc and iron, effects of complexation with cysteine, and an ATPase-coupled efflux [J]. Comp Biochem Physiol C Toxicol Pharmacol, 2012, 155(2): 238-246.
    [29]
    DJUKIC-COSIC D, CURCIC JOVANOVIC M, PLAMENAC BULAT Z, et al. Relation between lipid peroxidation and iron concentration in mouse liver after acute and subacute cadmium intoxication [J]. J Trace Elem Med Biol, 2008, 22(1): 66-72.
    [30]
    CHMIELNICKA J, CHERIAN M G. Environmental exposure to cadmium and factors affecting trace-element metabolism and metal toxicity [J]. Biol Trace Elem Res, 1986, 10(3): 243-262.
    [31]
    GROTEN J P, SINKELDAM E J, MUYS T, et al. Interaction of dietary Ca, P, Mg, Mn, Cu, Fe, Zn and Se with the accumulation and oral toxicity of cadmium in rats [J]. Food Chem Toxicol, 1991, 29(4): 249-258.
    [32]
    BAUER R, DEMETER I, HASEMANN V, et al. Structural properties of the zinc site in Cu,Zn-superoxide dismutase; Perturbed angular correlation of gamma ray spectroscopy on the Cu, 11Cd-superoxide dismutase derivative [J]. Biochemical and Biophysical Research Communications, 1980, 94(4): 1296-1302.
    [33]
    JIHEN EL H, FATIMA H, NOUHA A, et al. Cadmium retention increase: a probable key mechanism of the protective effect of zinc on cadmium-induced toxicity in the kidney [J]. Toxicol Lett, 2010, 196(2): 104-109.
    [34]
    KUWANO T, NAKAO S, YAMAMOTO H, et al. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis [J]. Faseb J, 2004, 18(2): 300-310.
    [35]
    PORTER D W, MILLECCHIA L L, WILLARD P, et al. Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation [J]. Toxicol Sci, 2006, 90(1): 188-197.
    [36]
    MOULIS J M. Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals [J]. Biometals, 2010, 23(5): 877-896.)
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