[1] |
Swanson K V, Deng M, Ting J P. The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nat Rev Immunol, 2019, 19(8): 477-489.
|
[2] |
Hara H, Tsuchiya K, Kawamura I, et al. Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity. Nat Immunol, 2013, 14(12): 1247-1255.
|
[3] |
Martinon F, Burns K, Tschopp J. The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell, 2002, 10(2): 417-426.
|
[4] |
He W T, Wan H, Hu L, et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion. Cell Res, 2015, 25(12): 1285-1298.
|
[5] |
Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature, 2015, 526(7575): 660-665.
|
[6] |
Kelley N, Jeltema D, Duan Y, et al. The NLRP3 inflammasome: An overview of mechanisms of activation and regulation. Int J Mol Sci, 2019, 20(13): 3328.
|
[7] |
Gong T, Jiang W, Zhou R. Control of inflammasome activation by phosphorylation. Trends Biochem Sci, 2018, 43(9): 685-699.
|
[8] |
Song N, Li T. Regulation of NLRP3 inflammasome by phosphorylation. Front Immunol, 2018, 9: 2305.
|
[9] |
Ubersax J A, Ferrell J E, Jr. Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol, 2007, 8(7): 530-541.
|
[10] |
Ardito F, Giuliani M, Perrone D, et al. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review). Int J Mol Med, 2017, 40(2): 271-280.
|
[11] |
He Y, Zeng M Y, Yang D, et al. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature, 2016, 530(7590): 354-357.
|
[12] |
Schmid-Burgk J L, Chauhan D, Schmidt T, et al. A Genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation. J Biol Chem, 2016, 291(1): 103-109.
|
[13] |
Shi H, Wang Y, Li X, et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol, 2016, 17(3): 250-258.
|
[14] |
Spalinger M R, Kasper S, Gottier C, et al. NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. J Clin Invest, 2016, 126(5): 1783-1800.
|
[15] |
Spalinger M R, Lang S, Gottier C, et al. PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner. Autophagy, 2017, 13(9): 1590-1601.
|
[16] |
Xiao Y, Tang J, Lin G, et al. Tyrosine phosphorylation of NLRP3 by Src family protein tyrosine kinase Lyn suppresses NLRP3 inflammasome activation. J Immunol,2020,204:68.19.
|
[17] |
Shio M T, Eisenbarth S C, Savaria M, et al. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog, 2009, 5(8): e1000559.
|
[18] |
Becker C E, Creagh E M, O’Neill L A. Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion. J Biol Chem, 2009, 284(50): 34531-34537.
|
[19] |
Mortimer L, Moreau F, MacDonald J A, et al. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations. Nat Immunol, 2016, 17(10): 1176-1186.
|
[20] |
Guo C, Xie S, Chi Z, et al. Bile Acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome. Immunity, 2016, 45(4): 802-816.
|
[21] |
Zhang Z, Meszaros G, He W T, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med, 2017, 214(9): 2671-2693.
|
[22] |
Dufies O, Doye A, Courjon J, et al. Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice. Nat Microbiol, 2021, 6(3): 401-412.
|
[23] |
Ting J P, Lovering R C, Alnemri E S, et al. The NLR gene family: A standard nomenclature. Immunity, 2008, 28(3): 285-287.
|
[24] |
Stutz A, Kolbe C C, Stahl R, et al. NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med, 2017, 214(6): 1725-1736.
|
[25] |
Huang Y, Wang H, Hao Y, et al. Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nat Cell Biol, 2020, 22(6): 716-727.
|
[26] |
Zhang A, Xing J, Xia T, et al. EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells. EMBO Rep, 2020, 21(7): e49666.
|
[27] |
Song N, Liu Z S, Xue W, et al. NLRP3 phosphorylation is an essential priming event for inflammasome activation. Mol Cell, 2017, 68(1): 185-197.e6.
|
[28] |
Ren G, Zhang X, Xiao Y, et al. ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination. EMBO J, 2019, 38(6):e100376.
|
[29] |
Martin B N, Wang C, Willette-Brown J, et al. IKKalpha negatively regulates ASC-dependent inflammasome activation. Nat Commun, 2014, 5: 4977.
|
[30] |
Mambwe B, Neo K, Javanmard Khameneh H, et al. Tyrosine dephosphorylation of ASC modulates the activation of the NLRP3 and AIM2 inflammasomes. Front Immunol, 2019, 10: 1556.
|
[31] |
Chung I C, OuYang C N, Yuan S N, et al. Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis. Sci Rep, 2016, 6: 36214.
|
[32] |
Gavrilin M A, Prather E R, Vompe A D, et al. cAbl kinase regulates inflammasome activation and pyroptosis via ASC phosphorylation. J Immunol, 2021, 206(6):1329-1336.
|
[33] |
Okada M, Matsuzawa A, Yoshimura A, et al. The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. J Biol Chem, 2014, 289(47): 32926-32936.
|
[34] |
Basak C, Pathak S K, Bhattacharyya A, et al. NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. J Biol Chem, 2005, 280(6): 4279-4288.
|
[35] |
Yang X D, Li W, Zhang S, et al. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J, 2020, 39(2): e102201.
|
[36] |
Samir P, Kesavardhana S, Patmore D M, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature, 2019, 573(7775): 590-594.
|
[37] |
Gu L, Fullam A, Brennan R, et al. Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation. Mol Cell Biol, 2013, 33(10): 2004-2015.
|
[38] |
Ito M, Shichita T, Okada M, et al. Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury. Nat Commun, 2015, 6: 7360.
|
[39] |
Liu X, Pichulik T, Wolz O O, et al. Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase. J Allergy Clin Immunol, 2017, 140(4): 1054-1067.e10.
|
[40] |
Weber A N R. Targeting the NLRP3 inflammasome via BTK. Front Cell Dev Biol, 2021, 9: 630479.
|
[41] |
Purvis G S D, Collino M, Aranda-Tavio H, et al. Inhibition of Bruton’s TK regulates macrophage NF-kappaB and NLRP3 inflammasome activation in metabolic inflammation. Br J Pharmacol, 2020, 177(19): 4416-4432.
|
[42] |
O’Riordan C E, Purvis G S D, Collotta D, et al. Bruton’styrosine kinase inhibition attenuates the cardiac dysfunction caused by cecal ligation and puncture in mice. Front Immunol, 2019, 10: 2129.
|
[43] |
Hussein M, Chai D C, Kyama C M, et al. c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: An assessor-blind placebo-controlled randomized study. Fertil Steril, 2016, 105(3): 815-824.e5.
|
[44] |
Zhang P, Liu Y, Jia L, et al. SP600125, a JNK-specific inhibitor, regulates in vitro auricular cartilage regeneration by promoting cell proliferation and inhibiting extracellular matrix metabolism. Front Cell Dev Biol, 2021, 9: 630678.
|
[45] |
Liang Z, Damianou A, Di Daniel E, et al. Inflammasome activation controlled by the interplay between post-translational modifications: Emerging drug target opportunities. Cell Commun Signal, 2021, 19(1): 23.
|
[1] |
Swanson K V, Deng M, Ting J P. The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nat Rev Immunol, 2019, 19(8): 477-489.
|
[2] |
Hara H, Tsuchiya K, Kawamura I, et al. Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity. Nat Immunol, 2013, 14(12): 1247-1255.
|
[3] |
Martinon F, Burns K, Tschopp J. The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell, 2002, 10(2): 417-426.
|
[4] |
He W T, Wan H, Hu L, et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion. Cell Res, 2015, 25(12): 1285-1298.
|
[5] |
Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature, 2015, 526(7575): 660-665.
|
[6] |
Kelley N, Jeltema D, Duan Y, et al. The NLRP3 inflammasome: An overview of mechanisms of activation and regulation. Int J Mol Sci, 2019, 20(13): 3328.
|
[7] |
Gong T, Jiang W, Zhou R. Control of inflammasome activation by phosphorylation. Trends Biochem Sci, 2018, 43(9): 685-699.
|
[8] |
Song N, Li T. Regulation of NLRP3 inflammasome by phosphorylation. Front Immunol, 2018, 9: 2305.
|
[9] |
Ubersax J A, Ferrell J E, Jr. Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol, 2007, 8(7): 530-541.
|
[10] |
Ardito F, Giuliani M, Perrone D, et al. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review). Int J Mol Med, 2017, 40(2): 271-280.
|
[11] |
He Y, Zeng M Y, Yang D, et al. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature, 2016, 530(7590): 354-357.
|
[12] |
Schmid-Burgk J L, Chauhan D, Schmidt T, et al. A Genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation. J Biol Chem, 2016, 291(1): 103-109.
|
[13] |
Shi H, Wang Y, Li X, et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol, 2016, 17(3): 250-258.
|
[14] |
Spalinger M R, Kasper S, Gottier C, et al. NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. J Clin Invest, 2016, 126(5): 1783-1800.
|
[15] |
Spalinger M R, Lang S, Gottier C, et al. PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner. Autophagy, 2017, 13(9): 1590-1601.
|
[16] |
Xiao Y, Tang J, Lin G, et al. Tyrosine phosphorylation of NLRP3 by Src family protein tyrosine kinase Lyn suppresses NLRP3 inflammasome activation. J Immunol,2020,204:68.19.
|
[17] |
Shio M T, Eisenbarth S C, Savaria M, et al. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog, 2009, 5(8): e1000559.
|
[18] |
Becker C E, Creagh E M, O’Neill L A. Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion. J Biol Chem, 2009, 284(50): 34531-34537.
|
[19] |
Mortimer L, Moreau F, MacDonald J A, et al. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations. Nat Immunol, 2016, 17(10): 1176-1186.
|
[20] |
Guo C, Xie S, Chi Z, et al. Bile Acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome. Immunity, 2016, 45(4): 802-816.
|
[21] |
Zhang Z, Meszaros G, He W T, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med, 2017, 214(9): 2671-2693.
|
[22] |
Dufies O, Doye A, Courjon J, et al. Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice. Nat Microbiol, 2021, 6(3): 401-412.
|
[23] |
Ting J P, Lovering R C, Alnemri E S, et al. The NLR gene family: A standard nomenclature. Immunity, 2008, 28(3): 285-287.
|
[24] |
Stutz A, Kolbe C C, Stahl R, et al. NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med, 2017, 214(6): 1725-1736.
|
[25] |
Huang Y, Wang H, Hao Y, et al. Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nat Cell Biol, 2020, 22(6): 716-727.
|
[26] |
Zhang A, Xing J, Xia T, et al. EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells. EMBO Rep, 2020, 21(7): e49666.
|
[27] |
Song N, Liu Z S, Xue W, et al. NLRP3 phosphorylation is an essential priming event for inflammasome activation. Mol Cell, 2017, 68(1): 185-197.e6.
|
[28] |
Ren G, Zhang X, Xiao Y, et al. ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination. EMBO J, 2019, 38(6):e100376.
|
[29] |
Martin B N, Wang C, Willette-Brown J, et al. IKKalpha negatively regulates ASC-dependent inflammasome activation. Nat Commun, 2014, 5: 4977.
|
[30] |
Mambwe B, Neo K, Javanmard Khameneh H, et al. Tyrosine dephosphorylation of ASC modulates the activation of the NLRP3 and AIM2 inflammasomes. Front Immunol, 2019, 10: 1556.
|
[31] |
Chung I C, OuYang C N, Yuan S N, et al. Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis. Sci Rep, 2016, 6: 36214.
|
[32] |
Gavrilin M A, Prather E R, Vompe A D, et al. cAbl kinase regulates inflammasome activation and pyroptosis via ASC phosphorylation. J Immunol, 2021, 206(6):1329-1336.
|
[33] |
Okada M, Matsuzawa A, Yoshimura A, et al. The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. J Biol Chem, 2014, 289(47): 32926-32936.
|
[34] |
Basak C, Pathak S K, Bhattacharyya A, et al. NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. J Biol Chem, 2005, 280(6): 4279-4288.
|
[35] |
Yang X D, Li W, Zhang S, et al. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J, 2020, 39(2): e102201.
|
[36] |
Samir P, Kesavardhana S, Patmore D M, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature, 2019, 573(7775): 590-594.
|
[37] |
Gu L, Fullam A, Brennan R, et al. Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation. Mol Cell Biol, 2013, 33(10): 2004-2015.
|
[38] |
Ito M, Shichita T, Okada M, et al. Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury. Nat Commun, 2015, 6: 7360.
|
[39] |
Liu X, Pichulik T, Wolz O O, et al. Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase. J Allergy Clin Immunol, 2017, 140(4): 1054-1067.e10.
|
[40] |
Weber A N R. Targeting the NLRP3 inflammasome via BTK. Front Cell Dev Biol, 2021, 9: 630479.
|
[41] |
Purvis G S D, Collino M, Aranda-Tavio H, et al. Inhibition of Bruton’s TK regulates macrophage NF-kappaB and NLRP3 inflammasome activation in metabolic inflammation. Br J Pharmacol, 2020, 177(19): 4416-4432.
|
[42] |
O’Riordan C E, Purvis G S D, Collotta D, et al. Bruton’styrosine kinase inhibition attenuates the cardiac dysfunction caused by cecal ligation and puncture in mice. Front Immunol, 2019, 10: 2129.
|
[43] |
Hussein M, Chai D C, Kyama C M, et al. c-Jun NH2-terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: An assessor-blind placebo-controlled randomized study. Fertil Steril, 2016, 105(3): 815-824.e5.
|
[44] |
Zhang P, Liu Y, Jia L, et al. SP600125, a JNK-specific inhibitor, regulates in vitro auricular cartilage regeneration by promoting cell proliferation and inhibiting extracellular matrix metabolism. Front Cell Dev Biol, 2021, 9: 630678.
|
[45] |
Liang Z, Damianou A, Di Daniel E, et al. Inflammasome activation controlled by the interplay between post-translational modifications: Emerging drug target opportunities. Cell Commun Signal, 2021, 19(1): 23.
|