ISSN 0253-2778

CN 34-1054/N

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Determination of α-tocopherol using positive scan polarization reverse catalytic voltammetry

  • Department of Chemistry, University of Science and Technology of China, Hefei230026, China

Cite this:
https://doi.org/10.3969/j.issn.0253-2778.2018.03.002
  • Received Date: 18 April 2017
  • Rev Recd Date: 20 June 2017
  • Publish Date: 31 March 2018
    Abstract

  • Abstract

    Silver oxide nanoparticles were formed at the surface of a silver electrode with anodic polarization, then the carboxyl graphene-nanosheets were electrodeposited on the silver oxide with cyclic potential scanning, and the graphene/silver oxide/silver electrode was successfully prepared and applied in detection of α-tocopherol in the alkaline medium. The electrochemical behavior and the electrocatalytic activity of the modified electrode were investigated using cyclic voltammetry. The α-tocopherol was detected by means of this modified electrode and the positive scan polarization reverse catalytic voltammetry. The experimental results demonstrate that the thus-prepared modified electrode is stable and has high sensitivity. Two linear relationships between the difference value peak current and the α-tocopherol concentration are obtained in the range of 0.02~0.32 μmol/L and 0.32~4.0 μmol/L respectively, with a limit of detection reaching 0.01 μmol/L.

    Abstract

    Silver oxide nanoparticles were formed at the surface of a silver electrode with anodic polarization, then the carboxyl graphene-nanosheets were electrodeposited on the silver oxide with cyclic potential scanning, and the graphene/silver oxide/silver electrode was successfully prepared and applied in detection of α-tocopherol in the alkaline medium. The electrochemical behavior and the electrocatalytic activity of the modified electrode were investigated using cyclic voltammetry. The α-tocopherol was detected by means of this modified electrode and the positive scan polarization reverse catalytic voltammetry. The experimental results demonstrate that the thus-prepared modified electrode is stable and has high sensitivity. Two linear relationships between the difference value peak current and the α-tocopherol concentration are obtained in the range of 0.02~0.32 μmol/L and 0.32~4.0 μmol/L respectively, with a limit of detection reaching 0.01 μmol/L.
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    • References(23)
  • [1]
    EVANS H M, BURR G O. Vitamin E: The ineffectiveness of curative dosage when mixed with diets containing high proportions of certain fats[J]. Journal of the American Medical Association, 1927, 88(19): 1462-1465.
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    FARINA N, ISAAC M G E K N, CLARK A R, et al. Vitamin E for Alzheimer's dementia and mild cognitive impairment[J]. Cochrane Database of Systematic Reviews, 2012 , 11 (11) :CD002854
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    KIVAK B, MERT T. Quantitative determination of α-tocopherol in Arbutus unedo by TLC-densitometry and colorimetry[J]. Fitoterapia, 2001, 72(6): 656-661.
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    KAND’R R, NOVOTN P, DRBKOV P. Determination of retinol,-tocopherol, lycopene, and-carotene in human plasma using HPLC with UV-Vis detection: Application to a clinical study[J]. Journal of Chemistry, 2012, 2013.
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    CITOVA I, HAVLIKOVA L, URBANEK L, et al. Comparison of a novel ultra-performance liquid chromatographic method for determination of retinol and α-tocopherol in human serum with conventional HPLC using monolithic and particulate columns[J]. Analytical and Bioanalytical Chemistry, 2007, 388(3): 675-681.
    [13]
    ZIYATDINOVA G, MOROZOV M, BUDNIKOV H. MWNT-modified electrodes for voltammetric determination of lipophilic vitamins[J]. Journal of Solid State Electrochemistry, 2012, 16(7): 2441-2447.
    [14]
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    WU S, ZHANG Z, ZHAO Q, et al. Electrocatalytic oxidation of saccharides at MoOx/AuNPs modified electrode towards analytical application[J]. Chinese Journal of Chemical Physics, 2014, 27(5): 600-606.
    [16]
    WANG L, WU S, SHI T, et al. Electrocatalytic oxidation of calcium folinate on carboxyl graphene modified CuxO/Cu electrode[J]. Chinese Journal of Chemical Physics, 2016, 29(6):729.
    [17]
    YAMAMOTO Y, NISHIHARA H, ARAMAKI K. Self-assembled layers of alkanethiols on copper for protection against corrosion[J]. Journal of the Electrochemical Society, 1993, 140(2): 436-443.
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    ITOH M, NISHIHARA H, ARAMAKI K. The protection ability of 11-mercapto-1-undecanol self-assembled monolayer modified with alkyltrichlorosilanes against corrosion of copper[J]. Journal of the Electrochemical Society, 1995, 142(6): 1839-1846.
    [19]
    ZAMORA-GARCIA I R, ALATORRE-ORDAZ A, IBANEZ J G, et al. Thermodynamic and electrochemical study on the mechanism of formation of Ag (OH) 4-in alkaline media[J]. Electrochimica Acta, 2013, 111: 268-274.
    [20]
    万晔，王秀梅，张扬，等. 银在氢氧化钠溶液中的电化学行为[J].中国有色金属学报, 2014, 24(2): 5-541.
    WAN Ye, WANG Xiumei, ZHANG Yang, et al.Electrochemical behavior of silver in NaOH solution[J]. The Chinese Journal of Nonferrous Metals, 2014, 24(2): 5-541.
    [21]
    WEBSTER R D. New insights into the oxidative electrochemistry of vitamin E[J]. Accounts of Chemical Research, 2007, 40(4): 251-257.
    [22]
    TAN Y S, CHEN S, HONG W M, et al. The role of low levels of water in the electrochemical oxidation of α-tocopherol (vitamin E) and other phenols in acetonitrile[J]. Physical Chemistry Chemical Physics, 2011, 13(28): 12745-12754.
    [23]
    FILIK H, AVAN A A, AYDAR S, et al. Determination of tocopherol using reduced graphene oxide-nafion hybrid-modified electrode in pharmaceutical capsules and vegetable oil samples[J]. Food Analytical Methods, 2016, 9(6): 1745-1753.
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    [1]
    EVANS H M, BURR G O. Vitamin E: The ineffectiveness of curative dosage when mixed with diets containing high proportions of certain fats[J]. Journal of the American Medical Association, 1927, 88(19): 1462-1465.
    [2]
    RUPEREZ F J, MARTIN D, HERRERA E, et al. Chromatographic analysis of α-tocopherol and related compounds in various matrices[J]. Journal of Chromatography A, 2001, 935(1): 45-69.
    [3]
    FARINA N, ISAAC M G E K N, CLARK A R, et al. Vitamin E for Alzheimer's dementia and mild cognitive impairment[J]. Cochrane Database of Systematic Reviews, 2012 , 11 (11) :CD002854
    [4]
    BERMAN K, BRODATY H. Tocopherol (vitamin E) in Alzheimer’s disease and other neurodegenerative disorders[J]. CNS Drugs, 2004, 18(12): 807-825.
    [5]
    KIVAK B, MERT T. Quantitative determination of α-tocopherol in Arbutus unedo by TLC-densitometry and colorimetry[J]. Fitoterapia, 2001, 72(6): 656-661.
    [6]
    DEMIRKAYA-MILOGLU F, KADIOGLU Y, SENOL O, et al. Spectrofluorimetric determination of α-tocopherol in capsules and human plasma[J]. Indian Journal Of Pharmaceutical Sciences, 2013, 75(5): 563.
    [7]
    CERVINKOVA B, KRCMOVA L K, SOLICHOVA D, et al. Recent advances in the determination of tocopherols in biological fluids: From sample pretreatment and liquid chromatography to clinical studies[J]. Analytical and Bioanalytical Chemistry, 2016, 408(10): 2407-2424.
    [8]
    DU M, AHN D U. Simultaneous analysis of tocopherols, cholesterol, and phytosterols using gas chromatography[J]. Journal Of Food Science, 2002, 67(5): 1696-1700.
    [9]
    HUSSAIN N, JABEEN Z, LI Y, et al. Detection of tocopherol in oilseed rape (Brassica napus L.) using gas chromatography with flame ionization detector[J]. Journal of Integrative Agriculture, 2013, 12(5): 803-814.
    [10]
    PYKA A, NABIAKOWSKA D, BOBER K, et al. Comparison of NP-TLC and RP-TLC with densitometry to quantitative analysis of tocopherol acetate in pharmaceutical preparation[J]. Journal of Liquid Chromatography & Related Technologies, 2011, 34(20): 2548-2564.
    [11]
    KAND’R R, NOVOTN P, DRBKOV P. Determination of retinol,-tocopherol, lycopene, and-carotene in human plasma using HPLC with UV-Vis detection: Application to a clinical study[J]. Journal of Chemistry, 2012, 2013.
    [12]
    CITOVA I, HAVLIKOVA L, URBANEK L, et al. Comparison of a novel ultra-performance liquid chromatographic method for determination of retinol and α-tocopherol in human serum with conventional HPLC using monolithic and particulate columns[J]. Analytical and Bioanalytical Chemistry, 2007, 388(3): 675-681.
    [13]
    ZIYATDINOVA G, MOROZOV M, BUDNIKOV H. MWNT-modified electrodes for voltammetric determination of lipophilic vitamins[J]. Journal of Solid State Electrochemistry, 2012, 16(7): 2441-2447.
    [14]
    KONDO T, SAKAI K, WATANABE T, et al. Electrochemical detection of lipophilic antioxidants with high sensitivity at boron-doped diamond electrode[J]. Electrochimica Acta, 2013, 95: 205-211.
    [15]
    WU S, ZHANG Z, ZHAO Q, et al. Electrocatalytic oxidation of saccharides at MoOx/AuNPs modified electrode towards analytical application[J]. Chinese Journal of Chemical Physics, 2014, 27(5): 600-606.
    [16]
    WANG L, WU S, SHI T, et al. Electrocatalytic oxidation of calcium folinate on carboxyl graphene modified CuxO/Cu electrode[J]. Chinese Journal of Chemical Physics, 2016, 29(6):729.
    [17]
    YAMAMOTO Y, NISHIHARA H, ARAMAKI K. Self-assembled layers of alkanethiols on copper for protection against corrosion[J]. Journal of the Electrochemical Society, 1993, 140(2): 436-443.
    [18]
    ITOH M, NISHIHARA H, ARAMAKI K. The protection ability of 11-mercapto-1-undecanol self-assembled monolayer modified with alkyltrichlorosilanes against corrosion of copper[J]. Journal of the Electrochemical Society, 1995, 142(6): 1839-1846.
    [19]
    ZAMORA-GARCIA I R, ALATORRE-ORDAZ A, IBANEZ J G, et al. Thermodynamic and electrochemical study on the mechanism of formation of Ag (OH) 4-in alkaline media[J]. Electrochimica Acta, 2013, 111: 268-274.
    [20]
    万晔，王秀梅，张扬，等. 银在氢氧化钠溶液中的电化学行为[J].中国有色金属学报, 2014, 24(2): 5-541.
    WAN Ye, WANG Xiumei, ZHANG Yang, et al.Electrochemical behavior of silver in NaOH solution[J]. The Chinese Journal of Nonferrous Metals, 2014, 24(2): 5-541.
    [21]
    WEBSTER R D. New insights into the oxidative electrochemistry of vitamin E[J]. Accounts of Chemical Research, 2007, 40(4): 251-257.
    [22]
    TAN Y S, CHEN S, HONG W M, et al. The role of low levels of water in the electrochemical oxidation of α-tocopherol (vitamin E) and other phenols in acetonitrile[J]. Physical Chemistry Chemical Physics, 2011, 13(28): 12745-12754.
    [23]
    FILIK H, AVAN A A, AYDAR S, et al. Determination of tocopherol using reduced graphene oxide-nafion hybrid-modified electrode in pharmaceutical capsules and vegetable oil samples[J]. Food Analytical Methods, 2016, 9(6): 1745-1753.
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