ISSN 0253-2778

CN 34-1054/N

Open AccessOpen Access JUSTC

Genetic basis and mechanisms underlying human azoospermia

Cite this:
https://doi.org/10.3969/j.issn.0253-2778.2018.10.008
  • Received Date: 04 August 2018
  • Rev Recd Date: 02 September 2018
  • Publish Date: 31 October 2018
  • Any abnormalities occurring in spermatogenesis may lead to azoospermia, finally resulting in male infertility. However, the molecular basis and mechanisms underlying these defects remain unidentified. In this review, by analyzing the existing diagnosis and treatments of azoospermia and summarizing the latest research on human spermatogenetic abnormalities, the limitations of current investigations were summarized and new ideas were proposed for future research, in the hope of taking full advantages of our existing resources and technologies to discover the cause of azoospermia, reveal the pathogenesis and finally promote male reproductive health.
    Any abnormalities occurring in spermatogenesis may lead to azoospermia, finally resulting in male infertility. However, the molecular basis and mechanisms underlying these defects remain unidentified. In this review, by analyzing the existing diagnosis and treatments of azoospermia and summarizing the latest research on human spermatogenetic abnormalities, the limitations of current investigations were summarized and new ideas were proposed for future research, in the hope of taking full advantages of our existing resources and technologies to discover the cause of azoospermia, reveal the pathogenesis and finally promote male reproductive health.
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