Abstract: Photodynamic therapy (PDT) is an emerging treatment method that relies on oxygen. However, due to the insufficient oxygen supply to the blood vessels at the tumor site, the hypoxic microenvironment greatly inhibits the therapeutic effect of PDT. Therefore, how to alleviate the tumor hypoxia is the key issue of the development of PDT. Perfluorocarbon is a compound that can effectively carry oxygen and is one of the commonly used blood substitutes. We carry oxygen and photothermal drug Indocyanine Green (ICG) through PFC (bromide hepta-fluorooctane) nanoparticles, and coat the particles with red blood cell membranes for bionic camouflage to reduce the uptake of particles by macrophages, improve the circulation capacity of the particles and enhance the ability of the drug to accumulate in the tumor. In addition, we combine PDT to effectively alleviate the hypoxia in the tumor microenvironment, enhance the photodynamic effect, and provide new strategies for cancer therapies.