Abstract: Objective To explore the clinical significance of thrombin molecular marker in disseminated intrascular coagulation (DIC), which include thrombin-antithrombin complex (TAT), thrombomodulin (TM), plasmin-antiplasmin inhibitor complex (α2-plamininhibitor-plasmin complex,PIC) and tissue plasminogen activator inhibitor complex (t-PAIC) .Methods This study included 233 patients with bleeding tendency or thrombosis, according to the 2017 edition of the Chinese disseminated intravascular coagulation diagnostic score system (CDSS),who were divided into the dominant DIC group, pre-DIC group and non-DIC group. The differences in laboratory indicators between groups were compared, and its value in the early diagnosis of DIC was evaluated.The molecular markers were measured by qualitative chemiluminescence enzyme immunoassay performed on HISCL automated analyzers.All patients with suspected DIC were followed for 7 days to screen for development of overt-DIC.Results In patients with overt-DIC, TAT, TM, PIC were significantly higher than those in non-DIC patients, and t-PAIC was statistically insignificant between the overt-DIC and non-DIC groups. TAT, TM, PIC, t-PAIC levels were significantly higher in patients with pre-DIC than in non-DIC patients.The AUC shows that the combined diagnostic curve of TAT, TM, PIC, and t-PAIC is 0.887,and AUC combined PT, APTT, and D-D is 0.933.Conclusions The combination of TAT, TM, PIC and t-PAIC can improve the early diagnosis rate of DIC and provide optimal timing for early clinical intervention and treatment.