Abstract: A surface reconstruction method from the slice contours was proposed. First, feature points were extracted based on curvature feature, and they were resampled in order to get a unification of sampling points in each line (column). Then, the sampling points were interpolated to get a bi-cubic non-uniform B-spline surface. Finally, nodes were inserted on the surface based on distance feature at a certain control accuracy, and the new control points through the least-squares approximation method were calculated to get approximate surface within the permissible range error. Based on the characteristics of slice contours, B-spline cycle and non-cycle B-spline combined, and the calculation of closed and non-closed surface was discussed. It was found that the combination of interpolation and approximation makes the algorithm more rapid and practical.