Abstract: The antenna location of the distributed antenna system (DAS) determines the systems performance. Under the condition of satisfying the users needs for QoS, the DAS antenna efficiency was first defined and then different methods were adopted to optimize the antenna position so as to reduce the number of antennas and/or minimize the average minimum access distance, thus improving the antenna efficiency and ultimately reducing the cost and the total transmission power of the system. The analysis and simulation results show that the methods have achieved excellent performance.