Abstract: As an example of R & D of Biotechnology and Drugs at USTC, several monoclonal antibodies (Abs) have been prepared for applications in industrial and medicinal applications. The Ab against human α-interferon (IFN) was used to prepare the IFN affinity chromatography gel which can provide efficient means for the manufacture of IFNs. It made this key technique for manufacturing IFNs no longer rely on input. Based on these, Anhui Anke High Biotechnology INC was founded in 1995. One of the Abs against oncoprotein p185erbB-2/HER-2 was developed for the diagnostic reagent of the cancers overexpressing oncoprotein p185 such as breast cancer and ovary cancer. This diagnostic reagent was proved by SFDA in 2004. Another Ab against p185 which can inhibit growth and proliferation of cancers overexpressing p185 is being developed into a therapeutic antibody drug. In addition, the fragments with anti-platelet aggregation activities have been developed for a potential anti-thrombus drug by a pharmaceutical company based on the research of the Labs in our school. More achievements are being made at USTC and will be applyied to biotech industries.