Abstract: According to self-regulation theory, we explored the relationship between entrepreneurial motivation and entrepreneurial well-being. We developed a moderated mediation model of entrepreneurial commitment linking entrepreneurial motivation and entrepreneurial well-being. Using a sample of 209 entrepreneurs in different industries, we found that entrepreneurial motivation was positively related to entrepreneurial well-being and that this relationship was mediated by entrepreneurial commitment. We further found that the effect of entrepreneurial motivation on entrepreneurial commitment was contingent on the perceived entrepreneurial process. Finally, theoretical and practical implications were discussed for entrepreneurs to take appropriate self-management measures.