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CN 34-1054/N

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Action of glycine, lysine, tyrosine and methionine in Micromonospora echinospora

  • 1.

    College of Biological Science and Technology, Fuzhou University, Fuzhou 350002, China

  • 2.

    Shandong Academy of Enviromental Science, Jinan 250013, China

Cite this: JUSTC, 2009, 39(1): 101-105
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  • Received Date: October 25, 2007
  • Revised Date: April 20, 2008
  • Published Date: January 30, 2009
    Abstract
  • The promoters (amino acids) were screened out by the orthogonal design in the course of biosynthesis micronomicin from the mutant strain (Fzu-707) of Micromonospora echinospora. Certain amount of glycine, lysine, tyrosine and methionine was added to the original medium in a flask on the rotary shaker 220 r/min and incubated at 36 ℃. It was propitious to biosynthesize micronomicin in cells of Micromonospora echinospora. The fermentation time was shortened from 144 h to 104 h, the yield of micronomicin (u·mL-1) was increased about 20% compared with the control group and the production rate of micronomicin was increased about 60%.
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